Assisi and Orvieto Day Trip from Rome. Travel from Rome to Orvieto and Assisi on this full-day trip, and discover two charming towns set amid picture-perfect Italian countryside. Start your day in Orvieto to see its Gothic showstopper, Orvieto Cathedral, followed by lunch near Lake Trasimeno. Explore the UNESCO-listed town of Assisi in Umbria, learning about its patron, St Francis of Assisi, and then stop in Santa Maria degli Angeli to admire its 9th-century Basilica where the saint once worshiped. Book Now and Save 10%: Assisi and Orvieto Day Trip from Rome.