Siena Day Trip from Rome. Spend a day in beautiful Siena, Tuscany’s second-largest city, on a full-day excursion from Rome! After enjoying a scenic journey through the Lazio and Tuscan countryside, enjoy free time in Siena to get to know the city at your own pace. Meet back up with the group for a 3-course lunch, and then head out on an afternoon walking tour to see and learn about Siena Cathedral, Piazza del Campo and more. Book now and Save 20%: Siena Day Trip from Rome.